Firefighters were called to the scene at 4.40am on Friday with reports an out-of-control blaze was tearing through the building on Hill Street.

Fire and Rescue NSW (FRNSW) Acting Zone Commander Steve Evans said the fire had destroyed the building.

“Upon arrival they [firefighters] found a brick building, around 20 metres by 40 metres, was well alight,” he said.

“Crews have been fighting the fire in a defensive mode, from outside the building, due to wall and roof collapse.”

Police and ambulance crews have also been called to the site, however, there have been no reports of injuries.

At this stage the cause of the fire is unknown.

This is the second fire in just four months to rip through the former abattoir with investigations still underway into the earlier blaze on April 20.

At 4.15am on that date, Millthorpe and Blayney NSW RFS brigades were paged to assist Fire and Rescue NSW the blaze.

At the time the NSW RFS said the fire was quickly brought under control and the police are investigating the cause of the fire.

Zone Commander Evans said he expects NSW Rural Fire Service and FRNSW crews will remain on scene for a number of hours on Friday to ensure all hot spots within the building have been extinguished.

He has urged anyone with information on this fire to come forward.

“If you do see anything within the area please call Crime Stoppers,” he said.

Call Crime Stoppers on 1800 333 000.